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About BioRouter

UCSF BioRouter is an open-source, AI-powered research environment developed at the Baranzini Lab, UCSF.

Community

Join the BioRouter Slack

Open community for issue reporting, feature requests, and discussion. join.slack.com/t/ucsfbiorouter

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News

Latest updates

13
May

BioRouter v1.75.2 — Versa Bedrock works on first install

Headline fix: a fresh Versa API Bedrock setup with just an Access Key ID and Secret Access Key now succeeds on the first try. AWS_ENDPOINT_URL_BEDROCK is now a first-class config field pre-populated with the UCSF MuleSoft proxy URL, and the Rust provider builds an explicit Credentials object so the AWS SDK no longer falls through to ~/.aws/credentials. The misleading AWS_PROFILE default was removed, generic Bedrock / Azure provider cards no longer carry UCSF-specific copy, and the extension installer's uv sync now runs with an augmented PATH.

View the release notes →
13
May

BioRouter v1.75.1 — session-rename consistency fix

Bug fix patch. Renames (manual via the title pill or automatic via the LLM) now propagate consistently across the history list, the chat-tab title, and any open dashboard window. New sessionNameSync module centralizes the cache and broadcasts changes across views; user-set names are now authoritative and lock against later LLM auto-renames.

View the release notes →
12
May

BioRouter v1.75.0 — Dashboard Mode

New full-window canvas workspace for spawning, arranging, and running multiple chat sessions side-by-side on an infinite pannable surface. Refreshed chat input bar with a real-time context-window indicator, collapsible picker popover, and tighter typography. Reliability hardening: bounded session-results cache, capped SSE retries, normalized shell.openExternal URLs, and tighter paste-image limits.

View the release notes →
8
May

BioRouter v1.72.1 — Skills, .brxt, Workflows rename

First-class Skills system (install from .md or .zip) and the .brxt extension bundle format for one-drag installs with bundled skills, tools, and config. UI redesign with warm cream tones and flat surfaces. Latest models added: GPT-5.4, GPT-5.5, Claude Sonnet 4.6, Claude Opus 4.7. UCSF Versa Azure and AWS Bedrock appear in Provider Configuration. Recipes renamed to Workflows. Patch fixes GPT-5.5 reasoning_effort routing and skill disable enforcement.

View the release notes →
13
Apr

BioRouter v1.60.0 — provider model refresh

Model updates across providers (Claude Sonnet 4.6, GPT-5.2, Gemini 3), GPT-5.4 support via the OpenAI Responses API, simpler AWS Bedrock endpoint configuration, and a standalone CLI binary for all platforms.

View the release notes →
13
Apr

BioRouter v1.50.0 — Workflows rename across the codebase

Renamed recipe → workflow everywhere with a session-database migration (v7) that rewrites recipe_json columns to workflow_json, fixing the "Error Loading Sessions" upgrade path. Redesigned provider cards with UCSF default values for Azure OpenAI and Amazon Bedrock. Electron upgraded to 39.8.7.

View the release notes →
16
Mar

BioRouter office hours recording is available

Research Data Assets Office Hours: UCSF BioRouter Demo, Secure AI-Enabled Research Workflows. The recording walks through installation, usage, and issue reporting. UCSF affiliates only.

Watch the recording →
21
Jan

BioRouter v1.20.0 — multi-platform launch

Native installers for macOS Apple Silicon and Intel, Windows x64, and Linux Debian and RPM. Default models updated to Claude Sonnet 4 and GPT-4.1. Refreshed branding, simpler provider onboarding, and a complete documentation suite.

View the release notes →
2026
Event

BioRouter at UCSF Research AI Day

BioRouter was featured at UCSF Research AI Day, showing agentic workflows for biomedical research, the BAAM marketplace, and federated cross-institution collaboration.

BioRouter at UCSF Research AI Day
Starts at 2:46:23
 Watch on YouTube (starts at 2:46:23) →

Resources

Useful links

GitHub repository

BaranziniLab/BioRouter

The Baranzini Lab

baranzinilab.ucsf.edu

Bakar CHSI

Computational Health Sciences Institute

UCSF Academic Research Services

ars.ucsf.edu

UCSF Versa

Institutional AI platform

UCSF AI Research Day

ai.ucsf.edu/researchday

Contributors

Acknowledgements

The Baranzini Lab baranzinilab.ucsf.edu ↗

Gianmarco Bellucci Sergio Baranzini

Bakar Computational Health Science Institute (BCHSI) bakarinstitute.ucsf.edu ↗

Sharat Israni Marina Sirota

UCSF Academic Research Services (ARS) ars.ucsf.edu ↗

William Santo Evan Philps Rick Larson Oksana Gologorskaya

Open source inspirations

Goose CLI and desktop agent for full developer workflows (Block). BioRouter's primary upstream foundation.
Aider Open-source, Git-native CLI AI coding agent.
Cline Open-source interactive CLI coding agent.
OpenCode Open-source coding agent with multi-session and multi-provider support.
ForgeCode Terminal AI coding assistant for task planning and code generation.

Developer

About the developer

Wanjun Gu

Lead developer, Baranzini Lab, UCSF

wanjun.gu@ucsf.edu github.com/Broccolito Baranzini Lab